A woman with diabetes is having a dye study of her retina today. A dye goes into a vein in her arm, and the fundus camera shoots rapid pictures as the dye travels through the vessels at the back of her eye. She asks you what the pictures will show the doctor. Which answer is correct?
The pictures show blocked and leaking retinal blood vessels. This study is fundus angiography. A dye is injected into an arm vein, and the bloodstream carries it to the vessels of the eye within seconds. The fundus camera carries special filters that make the dye stand out as it flows. The three common findings are vascular obstructions, leakage, and neovascularization, which means the abnormal growth of new blood vessels. All three matter a great deal in diabetes.
Timing is the point of the test. The camera fires in a rapid sequence. The images record the vessels at set time intervals as the dye fills the whole vascular tree. A vessel that is blocked stays dark. A vessel that leaks lets dye spread into the tissue around it. Two dyes are used. Fluorescein is the dye for most routine angiograms. Indocyanine green is more specialized and is chosen to study the choroidal circulation, the vessel layer under the retina. It is also chosen when blood or fluid deposits on top of the choroid hide those vessels from fluorescein. Angiography sometimes images the iris as well. The angiogram pictures come out black and white.
Remember what the dye can and cannot tell you. It maps blood flow, so it answers questions about blockage, leakage, and new vessels. It is not a test of lens clarity, corneal shape, or eye pressure. A diabetic patient is sent for this study to find leaking vessels and new vessels early, while treatment still helps. Explaining what an angiogram looks for sits in the COA ophthalmic imaging content area.
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